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实验室概况Introduction

实验室概况

实验室负责人

周亚明,教授,博士生导师。

1992年获复旦大学化学系学士。同年,留校参加工作。

1997年获复旦大学化学系硕士,2003年获复旦大学化学系博士学位。

实验室及团队建设

重视科研环境和科研设备的投入,先后购置了高效液相色谱、液质联用仪、制备色谱、超低温反应器、PCR仪、荧光光谱仪、吸附仪、粉末衍射仪等基础科研仪器,引入了整套科研管理软件,实现了科研数据的交互式云端管理。

团队有在职教师8人,其中教授2人,副教授3人,副研究员1人,高级工程师2人,学科涵盖有机化学、物理化学、无机化学、结构化学。

团队与国内外高校、科研单位、医药公司的资深从业人员一直保持着良好的合作关系,围绕着新药研发及诊疗材料,建立了一支有专业技能和专业特色的研究团队。

科研及人才培养

团队先后承担或参与多个国家各类科研项目,包括:国家重点研发计划,国家自然科学基金重大项目,教育部创新团队项目,国家科技支撑计划项目,国家重点基础研究发展计划及各类国家自然科学基金项目。

团队先后与多家国际知名医药研发企业签订新药分子合成研究项目,开发过/在研新药包括:c-met、PIM、PI3K、BTK、IDO抑制剂等。

其中,受委托筛选的用于治疗甲状腺或肾癌的小分子新药已于2012年经FDA批准上市;受某企业委托,筛选了一种新型靶向肿瘤分子药物,目前处于FDA临床三期。

团队先后培养各类研究生40多人,目前在读研究生12人。毕业生中有高校教师、企业经理、行业骨干等。

Laboratory Overview

Laboratory Director

Professor Zhou Yaming, Doctoral Supervisor.

Received a Bachelor's degree from the Department of Chemistry, Fudan University in 1992, joining its faculty the same year.

Obtained a Master's degree from the Department of Chemistry, Fudan University in 1997, and a Ph.D. from the Department of Chemistry, Fudan University in 2003.

Laboratory and Team Development

We have acquired fundamental research instruments including high-performance liquid chromatography, liquid chromatography-mass spectrometry, preparative chromatography, ultra-low temperature reactors, PCR instruments, fluorescence spectrometers, adsorption instruments, powder diffractometers, etc. We have also introduced a complete set of research management software, achieving interactive cloud-based management of research data.

The team consists of 8 full-time faculty members, including 2 professors, 3 associate professors, 1 associate researcher, and 2 senior engineers. The disciplines covered include organic chemistry, physical chemistry, inorganic chemistry, and structural chemistry.

The team maintains good cooperative relationships with senior professionals from domestic and international universities, research institutions, and pharmaceutical companies. Focusing on new drug development and diagnostic/therapeutic materials, we have established a research team with professional skills and distinctive characteristics.

Research and Talent Cultivation

The team has undertaken or participated in numerous national research projects, including: National Key R&D Program, Major Program of National Natural Science Foundation of China, Ministry of Education Innovation Team Project, National Science and Technology Support Program, National Basic Research Program, and various National Natural Science Foundation projects.

The team has signed new drug development projects with several internationally renowned pharmaceutical R&D companies. Developed/in-development new drugs include: c-met, PIM, PI3K, BTK, IDO inhibitors, etc.

Among these, a small molecule drug for treating thyroid or kidney cancer, screened under commission, was approved by the FDA in 2012; commissioned by a company, a novel targeted tumor molecular drug has been screened and is currently in FDA Phase III clinical trials.

We have over 40 graduated students with 12 currently enrolled. Graduates include university faculty, corporate managers, industry leaders, etc.


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